Omega-3 (EPA/DHA)

What this is

EPA-only trials (REDUCE-IT, JELIS) more positive than EPA+DHA combos (STRENGTH, OMEMI neutral). AFib risk at >1g/day. Quality/oxidation matters.

Mechanism

Incorporates into cell membranes; lowers triglycerides; anti-inflammatory eicosanoid/resolvin synthesis; membrane fluidity

Dose & route

1-2g combined EPA+DHA/day; up to 4g EPA-only for HTG; aim for Omega-3 Index >8%

Citations

• https://www.nejm.org/doi/full/10.1056/NEJMoa1812792
• https://pubmed.ncbi.nlm.nih.gov/34505026/
• https://www.ahajournals.org/doi/10.1161/JAHA.119.013543

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