Rankings / Hormones & Endocrine
Elinzanetant (Lynkuet)
Hormones & Endocrine · NK1/NK3 dual receptor antagonist (non-hormonal)
Tier A-
Bottom line
Read Off Label grades Elinzanetant (Lynkuet) as A- (7.6/10) based on strong evidence, high benefit magnitude, and a low-med-risk safety profile.
Bayer; brand Lynkuet.
Typical use: 120 mg PO once daily — Rx.
What this is
Bayer; brand Lynkuet. The NK1 addition provides a sleep/mood advantage that may make elinzanetant the preferred non-hormonal VMS therapy where available — especially since liver monitoring isn't required (vs fezolinetant). Also being studied for endocrine-therapy-induced hot flashes in breast cancer survivors.
Mechanism
Dual neurokinin 1 + neurokinin 3 receptor antagonist; the NK1 component additionally improves sleep and mood vs fezolinetant's NK3-only mechanism; same hypothalamic KNDy-circuit normalization for VMS
Dose & route
120 mg PO once daily
Citations
- https://doi.org/10.1007/s40264-026-01663-9
- https://doi.org/10.1007/s40265-025-02231-8
- https://pubmed.ncbi.nlm.nih.gov/41028653/
- https://europepmc.org/article/PMC/12983373
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Common questions
- Does Elinzanetant (Lynkuet) work?
- Read Off Label rates the evidence for Elinzanetant (Lynkuet) as Strong and the benefit magnitude as high, producing an overall grade of A- (7.6/10). Bayer; brand Lynkuet.
- Is Elinzanetant (Lynkuet) safe?
- Elinzanetant (Lynkuet) has a low-med risk profile in published human data. Legal status: Rx (approved EMA/several countries 2025; FDA filing in progress). This is not medical advice — see the disclaimer.
- What is the typical dose for Elinzanetant (Lynkuet)?
- 120 mg PO once daily
- How does Elinzanetant (Lynkuet) work?
- Dual neurokinin 1 + neurokinin 3 receptor antagonist; the NK1 component additionally improves sleep and mood vs fezolinetant's NK3-only mechanism; same hypothalamic KNDy-circuit normalization for VMS
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.