Gonadorelin (GnRH)
Hormones · Pulsatile GnRH analog
Tier B
What this is
Becoming the go-to HCG replacement at US men's-health telehealth clinics due to HCG supply disruption and counterfeits. Very short half-life (~2-4 min) means subQ injection gives a brief pulse similar to physiological signaling. Listed by FDA as Category 1 (compounding allowed) unlike most other peptides.
Mechanism
Synthetic GnRH identical to endogenous hypothalamic decapeptide; stimulates pituitary LH/FSH when delivered pulsatilely; continuous delivery paradoxically desensitizes pituitary
Dose & route
TRT adjunct: 100-200 mcg subQ 2-3x/week
Citations
- https://pubmed.ncbi.nlm.nih.gov/2183162/
- https://pubmed.ncbi.nlm.nih.gov/18000275/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7232131/
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