Rankings / Hormones & Endocrine
Gonadorelin (GnRH)
Hormones & Endocrine · Pulsatile GnRH analog
Tier B+
Bottom line
Read Off Label grades Gonadorelin (GnRH) as B+ (7.2/10) based on strong evidence, med benefit magnitude, and a low-med-risk safety profile.
Becoming the go-to HCG replacement at US men's-health telehealth clinics due to HCG supply disruption and counterfeits.
Typical use: TRT adjunct: 100-200 mcg subQ 2-3x/week — Rx (LutrePulse discontinued; now compounded); Category 1 on 503A bulks — compounding allowed.
What this is
Becoming the go-to HCG replacement at US men's-health telehealth clinics due to HCG supply disruption and counterfeits. Very short half-life (~2-4 min) means subQ injection gives a brief pulse similar to physiological signaling. Listed by FDA as Category 1 (compounding allowed) unlike most other peptides.
Mechanism
Synthetic GnRH identical to endogenous hypothalamic decapeptide; stimulates pituitary LH/FSH when delivered pulsatilely; continuous delivery paradoxically desensitizes pituitary
Dose & route
TRT adjunct: 100-200 mcg subQ 2-3x/week
Citations
- https://pubmed.ncbi.nlm.nih.gov/2183162/
- https://pubmed.ncbi.nlm.nih.gov/18000275/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7232131/
- https://pubmed.ncbi.nlm.nih.gov/33859571/
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Common questions
- Does Gonadorelin (GnRH) work?
- Read Off Label rates the evidence for Gonadorelin (GnRH) as Strong and the benefit magnitude as med, producing an overall grade of B+ (7.2/10). Becoming the go-to HCG replacement at US men's-health telehealth clinics due to HCG supply disruption and counterfeits.
- Is Gonadorelin (GnRH) safe?
- Gonadorelin (GnRH) has a low-med risk profile in published human data. Legal status: Rx (LutrePulse discontinued; now compounded); Category 1 on 503A bulks — compounding allowed. This is not medical advice — see the disclaimer.
- What is the typical dose for Gonadorelin (GnRH)?
- TRT adjunct: 100-200 mcg subQ 2-3x/week
- How does Gonadorelin (GnRH) work?
- Synthetic GnRH identical to endogenous hypothalamic decapeptide; stimulates pituitary LH/FSH when delivered pulsatilely; continuous delivery paradoxically desensitizes pituitary
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.