Rankings / Hormones & Endocrine
Gonadorelin (GnRH)
Hormones & Endocrine · Pulsatile GnRH analog
Tier B+
Bottom line
Read Off Label grades Gonadorelin (GnRH) as B+ (7.2/10) based on strong evidence, med benefit magnitude, and a low-med-risk safety profile.
Becoming the go-to HCG replacement at US men's-health telehealth clinics due to HCG supply disruption and counterfeits.
Studied, labeled, or reported-use context: TRT adjunct: 100-200 mcg subQ 2-3x/week — Rx (LutrePulse discontinued; now compounded); Category 1 on 503A bulks — compounding allowed; not individualized guidance.
What the evidence says
Becoming the go-to HCG replacement at US men's-health telehealth clinics due to HCG supply disruption and counterfeits. Very short half-life (~2-4 min) means subQ injection gives a brief pulse similar to physiological signaling. Listed by FDA as Category 1 (compounding allowed) unlike most other peptides.
Mechanism
Synthetic GnRH identical to endogenous hypothalamic decapeptide; stimulates pituitary LH/FSH when delivered pulsatilely; continuous delivery paradoxically desensitizes pituitary
Studied, labeled, or reported dose & route
TRT adjunct: 100-200 mcg subQ 2-3x/week
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Gonadorelin (GnRH)'s effects?
- Read Off Label rates the evidence for Gonadorelin (GnRH) as Strong and the benefit magnitude as med, producing an overall grade of B+ (7.2/10). Becoming the go-to HCG replacement at US men's-health telehealth clinics due to HCG supply disruption and counterfeits.
- What safety findings are reported for Gonadorelin (GnRH)?
- Gonadorelin (GnRH) has a low-med risk profile in the database. Low-Med (injection site; ovarian hyperstimulation syndrome in women on fertility doses; desensitization if not dosed correctly) Legal status: Rx (LutrePulse discontinued; now compounded); Category 1 on 503A bulks — compounding allowed.
- What doses or routes are reported for Gonadorelin (GnRH)?
- TRT adjunct: 100-200 mcg subQ 2-3x/week This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Gonadorelin (GnRH) work?
- Synthetic GnRH identical to endogenous hypothalamic decapeptide; stimulates pituitary LH/FSH when delivered pulsatilely; continuous delivery paradoxically desensitizes pituitary
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.