Rankings / Hormones & Endocrine
Tadalafil (Cialis)
Hormones & Endocrine · Long-acting PDE5 inhibitor
Tier S
Bottom line
Read Off Label grades Tadalafil (Cialis) as S (8.8/10) based on very strong evidence, very strong benefit magnitude, and a low-med-risk safety profile.
Long half-life makes daily low-dose dosing feasible ('weekender' branding).
Studied, labeled, or reported-use context: 2. — Rx; generic since 2018; not individualized guidance.
Citation correction in progress
2 PubMed links were found to be unrelated to this entry and removed from public output. The remaining sources are shown below, but this row's claims and score still need a full source-by-source revalidation.
What the evidence says
Long half-life makes daily low-dose dosing feasible ('weekender' branding). BPH approval at 5 mg daily is useful for older men with ED+LUTS. Back/muscle pain is characteristic (via PDE11 cross-inhibition). Same CV cautions and food effects less pronounced than sildenafil.
Mechanism
Same mechanism as sildenafil but with ~17.5-hr plasma half-life — allows daily low-dose use for continuous effect rather than as-needed; also FDA-approved for BPH symptoms
Studied, labeled, or reported dose & route
2.5-5 mg PO daily (daily regimen) or 10-20 mg on-demand
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Tadalafil (Cialis)'s effects?
- Read Off Label rates the evidence for Tadalafil (Cialis) as Very Strong and the benefit magnitude as very strong, producing an overall grade of S (8.8/10). Long half-life makes daily low-dose dosing feasible ('weekender' branding).
- What safety findings are reported for Tadalafil (Cialis)?
- Tadalafil (Cialis) has a low-med risk profile in the database. Low-Med (headache, back/muscle pain distinctive of tadalafil, nasal congestion; same nitrate contraindication) Legal status: Rx; generic since 2018.
- What doses or routes are reported for Tadalafil (Cialis)?
- 2.5-5 mg PO daily (daily regimen) or 10-20 mg on-demand This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Tadalafil (Cialis) work?
- Same mechanism as sildenafil but with ~17.5-hr plasma half-life — allows daily low-dose use for continuous effect rather than as-needed; also FDA-approved for BPH symptoms
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.