Tadalafil (Cialis)
Libido · Long-acting PDE5 inhibitor
Tier A+
What this is
Long half-life makes daily low-dose dosing feasible ('weekender' branding). BPH approval at 5 mg daily is useful for older men with ED+LUTS. Back/muscle pain is characteristic (via PDE11 cross-inhibition). Same CV cautions and food effects less pronounced than sildenafil.
Mechanism
Same mechanism as sildenafil but with ~17.5-hr plasma half-life — allows daily low-dose use for continuous effect rather than as-needed; also FDA-approved for BPH symptoms
Dose & route
2.5-5 mg PO daily (daily regimen) or 10-20 mg on-demand
Citations
- https://pubmed.ncbi.nlm.nih.gov/16226412/
- https://pubmed.ncbi.nlm.nih.gov/22182305/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC2684510/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.