Rankings / Longevity — Peptides
Epithalon (epitalon)
Longevity · Pineal peptide bioregulator
Tier C+
Bottom line
Read Off Label grades Epithalon (epitalon) as C+ (5.3/10) based on preclinical evidence, variable benefit magnitude, and a low-risk safety profile.
Most data from Khavinson's Russian St.
Typical use: 5-10 mg SC/IM daily for 10-20 day courses, 1-2x/year — Research chemical.
What this is
Most data from Khavinson's Russian St. Petersburg Institute — limited Western peer-review. Claims of telomere lengthening in somatic cells. Interesting hypothesis but long-term cancer risk from telomerase activation unexamined.
Mechanism
Synthetic Ala-Glu-Asp-Gly tetrapeptide (Khavinson); proposed telomerase activation; pineal modulation; restoration of melatonin rhythm
Dose & route
5-10 mg SC/IM daily for 10-20 day courses, 1-2x/year
Citations
- https://pubmed.ncbi.nlm.nih.gov/12374906/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9565860/
- https://www.gethealthspan.com/research/article/epitalon
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does Epithalon (epitalon) work?
- Read Off Label rates the evidence for Epithalon (epitalon) as Preclinical and the benefit magnitude as variable, producing an overall grade of C+ (5.3/10). Most data from Khavinson's Russian St.
- Is Epithalon (epitalon) safe?
- Epithalon (epitalon) has a low risk profile in published human data. Legal status: Research chemical. This is not medical advice — see the disclaimer.
- What is the typical dose for Epithalon (epitalon)?
- 5-10 mg SC/IM daily for 10-20 day courses, 1-2x/year
- How does Epithalon (epitalon) work?
- Synthetic Ala-Glu-Asp-Gly tetrapeptide (Khavinson); proposed telomerase activation; pineal modulation; restoration of melatonin rhythm
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.