Rankings / Longevity — Peptides
MOTS-c
Longevity · Mitochondrial-derived peptide
Tier C
What this is
Reynolds 2020 Nature Commun: MOTS-c injection improved exercise performance in old mice to young-mouse levels. Circulating MOTS-c increases with exercise in humans. No published human RCTs for longevity endpoints. Very early stage.
Mechanism
Peptide encoded by mitochondrial 12S rRNA; activates AMPK; enhances glucose uptake and fatty acid oxidation; nuclear translocation to regulate stress-response genes; exercise-induced
Dose & route
5-10 mg SC 2-3x/week in cycles
Citations
- https://www.nature.com/articles/s41467-020-20790-0
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9905433/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9854231/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.