Rankings / Longevity — Peptides
MOTS-c
Longevity · Mitochondrial-derived peptide
Tier C+
Bottom line
Read Off Label grades MOTS-c as C+ (5.5/10) based on preclinical-weak human evidence, variable benefit magnitude, and a low-risk safety profile.
Reynolds 2020 Nature Commun: MOTS-c injection improved exercise performance in old mice to young-mouse levels.
Typical use: 5-10 mg SC 2-3x/week in cycles — Research chemical.
What this is
Reynolds 2020 Nature Commun: MOTS-c injection improved exercise performance in old mice to young-mouse levels. Circulating MOTS-c increases with exercise in humans. No published human RCTs for longevity endpoints. Very early stage.
Mechanism
Peptide encoded by mitochondrial 12S rRNA; activates AMPK; enhances glucose uptake and fatty acid oxidation; nuclear translocation to regulate stress-response genes; exercise-induced
Dose & route
5-10 mg SC 2-3x/week in cycles
Citations
- https://www.nature.com/articles/s41467-020-20790-0
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9905433/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9854231/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does MOTS-c work?
- Read Off Label rates the evidence for MOTS-c as Preclinical-Weak human and the benefit magnitude as variable, producing an overall grade of C+ (5.5/10). Reynolds 2020 Nature Commun: MOTS-c injection improved exercise performance in old mice to young-mouse levels.
- Is MOTS-c safe?
- MOTS-c has a low risk profile in published human data. Legal status: Research chemical. This is not medical advice — see the disclaimer.
- What is the typical dose for MOTS-c?
- 5-10 mg SC 2-3x/week in cycles
- How does MOTS-c work?
- Peptide encoded by mitochondrial 12S rRNA; activates AMPK; enhances glucose uptake and fatty acid oxidation; nuclear translocation to regulate stress-response genes; exercise-induced
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.