Hyperbaric oxygen therapy (HBOT)
Protocols · Oxygen/Pressure
Tier C+
What this is
Hachmo 2020: 60 HBOT sessions in older adults increased telomere length >20% and reduced senescent cells 10-37%. Expensive ($200-500/session). Not covered by insurance for anti-aging indications.
Mechanism
Hyperoxic-hypoxic paradox: high oxygen pressure increases tissue oxygenation then triggers HIF-1α response upon return to normoxia; stem cell mobilization; angiogenesis; reduced inflammation
Dose & route
2.0-2.4 ATA x 60-90 min; protocols vary; Hachmo aging trial used 60 sessions
Citations
- https://www.aging-us.com/article/202188/text
- https://pubmed.ncbi.nlm.nih.gov/33206062/
- https://www.frontiersin.org/journals/aging/articles/10.3389/fragi.2024.1368982/full
Links go to the source. If a link is dead or you want something re-checked, let me know.
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.