Rankings / Mood, Anxiety & Stress
Ibogaine
Mood, Anxiety & Stress · Iboga alkaloid / NMDA antagonist + kappa-opioid
Tier C-
Bottom line
Read Off Label grades Ibogaine as C- (4.0/10) based on weak-moderate evidence, high benefit magnitude, and a high-risk safety profile.
Highly cardiotoxic — real deaths from treatment-related arrhythmias.
Typical use: 10-25 mg/kg for opioid detox in clinic settings (medically supervised) — Schedule I US; legal in Mexico, Costa Rica, Portugal, some other countries; Gabon/Cameroon sacrament.
What this is
Highly cardiotoxic — real deaths from treatment-related arrhythmias. Requires ECG monitoring, exclusion of QT-prolonging meds, crash cart. Kentucky 2024 approved funding research for opioid use disorder. Stanford Nolan Williams 2024 TBI study in Special Forces veterans showed striking symptom improvements. Do not attempt without medical supervision.
Mechanism
Multi-target: NMDA antagonism, kappa-opioid agonism, nicotinic antagonism, sigma-2 activity; active metabolite noribogaine; used for opioid dependence interruption
Dose & route
10-25 mg/kg for opioid detox in clinic settings (medically supervised)
Citations
- https://pubmed.ncbi.nlm.nih.gov/37884730/
- https://pubmed.ncbi.nlm.nih.gov/29392216/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4441532/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does Ibogaine work?
- Read Off Label rates the evidence for Ibogaine as Weak-Moderate and the benefit magnitude as high, producing an overall grade of C- (4.0/10). Highly cardiotoxic — real deaths from treatment-related arrhythmias.
- Is Ibogaine safe?
- Ibogaine has a high risk profile in published human data. Legal status: Schedule I US; legal in Mexico, Costa Rica, Portugal, some other countries; Gabon/Cameroon sacrament. This is not medical advice — see the disclaimer.
- What is the typical dose for Ibogaine?
- 10-25 mg/kg for opioid detox in clinic settings (medically supervised)
- How does Ibogaine work?
- Multi-target: NMDA antagonism, kappa-opioid agonism, nicotinic antagonism, sigma-2 activity; active metabolite noribogaine; used for opioid dependence interruption
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.