Rankings / Cognitive — Nootropics
Ibogaine
Cognitive · Iboga alkaloid / NMDA antagonist + kappa-opioid
Tier C-
What this is
Highly cardiotoxic — real deaths from treatment-related arrhythmias. Requires ECG monitoring, exclusion of QT-prolonging meds, crash cart. Kentucky 2024 approved funding research for opioid use disorder. Stanford Nolan Williams 2024 TBI study in Special Forces veterans showed striking symptom improvements. Do not attempt without medical supervision.
Mechanism
Multi-target: NMDA antagonism, kappa-opioid agonism, nicotinic antagonism, sigma-2 activity; active metabolite noribogaine; used for opioid dependence interruption
Dose & route
10-25 mg/kg for opioid detox in clinic settings (medically supervised)
Citations
- https://pubmed.ncbi.nlm.nih.gov/37884730/
- https://pubmed.ncbi.nlm.nih.gov/29392216/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4441532/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.