KPV (Lys-Pro-Val)
Recovery · Tripeptide (alpha-MSH fragment)
Tier D+
What this is
Small peptide with anti-inflammatory preclinical signal especially for GI and skin. Popular in biohacker protocols for IBD, SIBO, eczema. Human evidence thin. FDA Jan 2025 compounding restriction applies.
Mechanism
C-terminal tripeptide of alpha-melanocyte-stimulating hormone; anti-inflammatory activity via melanocortin receptors; suppresses NF-κB; GI-tropic when given orally
Dose & route
200-500 mcg subQ daily or oral (anecdotal)
Citations
- https://pubmed.ncbi.nlm.nih.gov/26510751/
- https://pubmed.ncbi.nlm.nih.gov/29031186/
- https://www.fda.gov/media/174456/download
Links go to the source. If a link is dead or you want something re-checked, let me know.
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.