KPV (Lys-Pro-Val)
Sleep & Recovery · Tripeptide (alpha-MSH fragment)
Tier D
Bottom line
Read Off Label grades KPV (Lys-Pro-Val) as D (3.3/10) based on preclinical evidence, unclear benefit magnitude, and a unclear-risk safety profile.
Small peptide with anti-inflammatory preclinical signal especially for GI and skin.
Typical use: 200-500 mcg subQ daily or oral (anecdotal) — Not FDA-approved; Category 2 on 503A bulks (compounding prohibited); research peptide.
What this is
Small peptide with anti-inflammatory preclinical signal especially for GI and skin. Popular in biohacker protocols for IBD, SIBO, eczema. Human evidence thin. FDA Jan 2025 compounding restriction applies.
Mechanism
C-terminal tripeptide of alpha-melanocyte-stimulating hormone; anti-inflammatory activity via melanocortin receptors; suppresses NF-κB; GI-tropic when given orally
Dose & route
200-500 mcg subQ daily or oral (anecdotal)
Citations
- https://pubmed.ncbi.nlm.nih.gov/26510751/
- https://pubmed.ncbi.nlm.nih.gov/29031186/
- https://www.fda.gov/media/174456/download
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does KPV (Lys-Pro-Val) work?
- Read Off Label rates the evidence for KPV (Lys-Pro-Val) as Preclinical and the benefit magnitude as unclear, producing an overall grade of D (3.3/10). Small peptide with anti-inflammatory preclinical signal especially for GI and skin.
- Is KPV (Lys-Pro-Val) safe?
- KPV (Lys-Pro-Val) has a unclear risk profile in published human data. Legal status: Not FDA-approved; Category 2 on 503A bulks (compounding prohibited); research peptide. This is not medical advice — see the disclaimer.
- What is the typical dose for KPV (Lys-Pro-Val)?
- 200-500 mcg subQ daily or oral (anecdotal)
- How does KPV (Lys-Pro-Val) work?
- C-terminal tripeptide of alpha-melanocyte-stimulating hormone; anti-inflammatory activity via melanocortin receptors; suppresses NF-κB; GI-tropic when given orally
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.