LL-37 (cathelicidin)
Sleep & Recovery · Antimicrobial peptide
Tier D
Bottom line
Read Off Label grades LL-37 (cathelicidin) as D (3.3/10) based on preclinical evidence, unclear benefit magnitude, and a unclear-risk safety profile.
Used by some protocols targeting biofilm-associated chronic infections (CIRS/Lyme communities).
Typical use: No established human dosing protocol — Not FDA-approved; research peptide.
What this is
Used by some protocols targeting biofilm-associated chronic infections (CIRS/Lyme communities). Essentially no clinical trial safety data in humans for exogenous administration. Speculative application.
Mechanism
Endogenous cationic host-defense peptide from cathelicidin; broad antimicrobial activity; immunomodulatory and wound healing effects; VDR-regulated
Dose & route
No established human dosing protocol
Citations
- https://pubmed.ncbi.nlm.nih.gov/31618880/
- https://pubmed.ncbi.nlm.nih.gov/27006251/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6694145/
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Common questions
- Does LL-37 (cathelicidin) work?
- Read Off Label rates the evidence for LL-37 (cathelicidin) as Preclinical and the benefit magnitude as unclear, producing an overall grade of D (3.3/10). Used by some protocols targeting biofilm-associated chronic infections (CIRS/Lyme communities).
- Is LL-37 (cathelicidin) safe?
- LL-37 (cathelicidin) has a unclear risk profile in published human data. Legal status: Not FDA-approved; research peptide. This is not medical advice — see the disclaimer.
- What is the typical dose for LL-37 (cathelicidin)?
- No established human dosing protocol
- How does LL-37 (cathelicidin) work?
- Endogenous cationic host-defense peptide from cathelicidin; broad antimicrobial activity; immunomodulatory and wound healing effects; VDR-regulated
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.