Rankings / Longevity — Senolytics & Polyphenols
Quercetin
Longevity · Flavonoid / mild senolytic
Tier B
What this is
Weak standalone senolytic; more effective combined with dasatinib. Also used as zinc ionophore during respiratory infections. Exercise performance and BP benefits modest but consistent.
Mechanism
Plant flavonoid; zinc ionophore; mild senolytic when combined with dasatinib; anti-inflammatory via NF-κB inhibition; mast cell stabilizer
Dose & route
500-1000 mg/day; phytosome or bromelain-complex formulations improve absorption
Citations
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7070905/
- https://pubmed.ncbi.nlm.nih.gov/26933622/
- https://www.ebiomedicine.com/article/S2352-3964(18)30373-6/fulltext
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.