SPMs (specialized pro-resolving mediators)
Recovery · Lipid signaling molecules
Tier C-
What this is
Serhan's lab demonstrated that resolution is an active process, not merely shutoff of pro-inflammatory signaling. Supplements claim to deliver SPMs or their precursors. Evidence base is emerging but mostly preclinical. Expensive relative to ordinary fish oil with unclear marginal benefit.
Mechanism
Resolvins, protectins, maresins — lipid mediators derived from EPA/DHA/DPA that actively signal inflammation resolution (not just 'anti-inflammatory' — distinct resolution phase biology); discovered by Charles Serhan
Dose & route
~2 g/day SPM-enriched fish oil
Citations
- https://pubmed.ncbi.nlm.nih.gov/29431100/
- https://pubmed.ncbi.nlm.nih.gov/24927163/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8212707/
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