SPMs (specialized pro-resolving mediators)
Sleep & Recovery · Lipid signaling molecules
Tier C
Bottom line
Read Off Label grades SPMs (specialized pro-resolving mediators) as C (5.0/10) based on preclinical evidence, low-med benefit magnitude, and a low-risk safety profile.
Serhan's lab demonstrated that resolution is an active process, not merely shutoff of pro-inflammatory signaling.
Studied, labeled, or reported-use context: ~2 g/day SPM-enriched fish oil — OTC supplements (Metagenics, others) contain SPM-enriched fish oil fractions; not individualized guidance.
What the evidence says
Serhan's lab demonstrated that resolution is an active process, not merely shutoff of pro-inflammatory signaling. Supplements claim to deliver SPMs or their precursors. Evidence base is emerging but mostly preclinical. Expensive relative to ordinary fish oil with unclear marginal benefit.
Mechanism
Resolvins, protectins, maresins — lipid mediators derived from EPA/DHA/DPA that actively signal inflammation resolution (not just 'anti-inflammatory' — distinct resolution phase biology); discovered by Charles Serhan
Studied, labeled, or reported dose & route
~2 g/day SPM-enriched fish oil
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about SPMs (specialized pro-resolving mediators)'s effects?
- Read Off Label rates the evidence for SPMs (specialized pro-resolving mediators) as Preclinical and the benefit magnitude as low-med, producing an overall grade of C (5.0/10). Serhan's lab demonstrated that resolution is an active process, not merely shutoff of pro-inflammatory signaling.
- What safety findings are reported for SPMs (specialized pro-resolving mediators)?
- SPMs (specialized pro-resolving mediators) has a low risk profile in the database. Low (early data) Legal status: OTC supplements (Metagenics, others) contain SPM-enriched fish oil fractions.
- What doses or routes are reported for SPMs (specialized pro-resolving mediators)?
- ~2 g/day SPM-enriched fish oil This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does SPMs (specialized pro-resolving mediators) work?
- Resolvins, protectins, maresins — lipid mediators derived from EPA/DHA/DPA that actively signal inflammation resolution (not just 'anti-inflammatory' — distinct resolution phase biology); discovered by Charles Serhan
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.