Rankings / Base — Vitamins & Minerals
Vitamin D
Base · Vitamin
Tier B
What this is
VITAL trial: no mortality reduction overall in replete US population; meta-analyses show mortality benefit primarily when correcting deficiency. Lung cancer mortality signal.
Mechanism
Hormone/prohormone; regulates calcium/phosphate, immune modulation, bone health; possible cancer and CVD signaling
Dose & route
1000-5000 IU/day D3; aim for 25(OH)D of 30-50 ng/mL; pair with K2 and fat for absorption
Citations
- https://www.nejm.org/doi/full/10.1056/NEJMoa1809944
- https://pubmed.ncbi.nlm.nih.gov/31405892/
- https://www.nature.com/articles/s41574-021-00593-z
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.