What does the evidence show about Vitamin K2 (MK-7)'s effects?

Read Off Label rates the evidence for Vitamin K2 (MK-7) as Moderate and the benefit magnitude as med, producing an overall grade of B+ (7.1/10). Rotterdam Study: high dietary K2 associated with ~50% reduction in arterial calcification and CHD mortality.

What safety findings are reported for Vitamin K2 (MK-7)?

Vitamin K2 (MK-7) has a low risk profile in the database. Low (vitamin K can antagonize warfarin and alter anticoagulation) Legal status: OTC.

What doses or routes are reported for Vitamin K2 (MK-7)?

90-180 mcg/day MK-7 in cited studies and common supplement protocols This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.

Rankings / Essentials — Vitamins & Minerals

Vitamin K2 (MK-7)

Essentials · Vitamin

Also known as: Menaquinone-7 ·MK-7

Tier B+

Reviewed by Read Off Label · Last reviewed Jun 8, 2026 · How we grade

vitaminotc

7.1 / 10

Tier B+

Ev 6 Bn 5 Sf 9

Bottom line

Read Off Label grades Vitamin K2 (MK-7) as B+ (7.1/10) based on moderate evidence, med benefit magnitude, and a low-risk safety profile.

Rotterdam Study: high dietary K2 associated with ~50% reduction in arterial calcification and CHD mortality.

Studied, labeled, or reported-use context: 90-180 mcg/day MK-7 in cited studies and common supplement protocols — OTC; not individualized guidance.

What the evidence says

Rotterdam Study: high dietary K2 associated with ~50% reduction in arterial calcification and CHD mortality. RCT evidence for reversing arterial stiffness in postmenopausal women.

Mechanism

Activates matrix Gla protein (MGP) and osteocalcin — directs calcium to bones and away from arteries

Studied, labeled, or reported dose & route

90-180 mcg/day MK-7 in cited studies and common supplement protocols

This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.

Citations

A link means the source informed this entry; it does not mean every claim on the page comes from that source. If a citation looks wrong or you want a claim re-checked, send a correction.

Common questions

What does the evidence show about Vitamin K2 (MK-7)'s effects?: Read Off Label rates the evidence for Vitamin K2 (MK-7) as Moderate and the benefit magnitude as med, producing an overall grade of B+ (7.1/10). Rotterdam Study: high dietary K2 associated with ~50% reduction in arterial calcification and CHD mortality.
What safety findings are reported for Vitamin K2 (MK-7)?: Vitamin K2 (MK-7) has a low risk profile in the database. Low (vitamin K can antagonize warfarin and alter anticoagulation) Legal status: OTC.
What doses or routes are reported for Vitamin K2 (MK-7)?: 90-180 mcg/day MK-7 in cited studies and common supplement protocols This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
How does Vitamin K2 (MK-7) work?: Activates matrix Gla protein (MGP) and osteocalcin — directs calcium to bones and away from arteries

This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.