Rankings / Cognitive — Prescription Stimulants
Vyvanse (lisdexamfetamine)
Cognitive · Prescription stimulant
Tier B-
What this is
Prodrug design reduces euphoria and injection misuse potential. Also first FDA-approved drug for binge eating disorder. Same cardiovascular caution as Adderall. Generics now available in US.
Mechanism
L-lysine-conjugated d-amphetamine prodrug; cleaved in red blood cells to yield active d-amphetamine; smoother pharmacokinetics than Adderall with 10-14 hour duration
Dose & route
30-70 mg PO once daily morning
Citations
- https://pubmed.ncbi.nlm.nih.gov/25280017/
- https://pubmed.ncbi.nlm.nih.gov/25566970/
- https://pubmed.ncbi.nlm.nih.gov/19192458/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.