Rankings / Weight Loss
Weight Loss — Incretins & Amylin
GLP-1 agonists, GLP-1/GIP dual agonists, triple agonists, and amylin analogs. The modern obesity-pharma revolution.
| # | Compound | Ev | Bn | Sf | Grade · Score |
|---|---|---|---|---|---|
| 1 | Retatrutide GLP-1/GIP/glucagon agonist (triple) | 8.0 | 10.0 | 5.0 | B+ 7.4 |
| 2 | Semaglutide GLP-1 agonist | 8.0 | 8.0 | 5.0 | B+ 7.1 |
| 3 | Setmelanotide MC4R agonist | 8.0 | 8.0 | 5.0 | B+ 7.1 |
| 4 | Tirzepatide GLP-1/GIP agonist (dual) | 8.0 | 8.0 | 5.0 | B+ 7.1 |
| 5 | Mazdutide (IBI362) GLP-1/glucagon agonist (dual) | 8.0 | 8.0 | 5.0 | B+ 7.0 |
| 6 | Cagrilintide Amylin analog | 8.0 | 8.0 | 5.0 | B 6.9 |
| 7 | Maridebart cafraglutide (MariTide) GLP-1 agonist + GIP antagonist | 8.0 | 8.0 | 5.0 | B 6.9 |
| 8 | Orforglipron Oral GLP-1 agonist (small molecule) | 8.0 | 8.0 | 5.0 | B 6.9 |
| 9 | Survodutide GLP-1/glucagon agonist (dual) | 8.0 | 8.0 | 5.0 | B 6.9 |
| 10 | Liraglutide GLP-1 agonist | 8.0 | 6.5 | 5.0 | B 6.7 |
| 11 | Dulaglutide GLP-1 agonist | 8.0 | 5.0 | 5.0 | B- 6.3 |
| 12 | Pramlintide Amylin analog (short-acting) | 8.0 | 3.5 | 5.0 | B- 5.9 |