CoQ10 (ubiquinone/ubiquinol)
Base · Supplement
Tier A-
mitochondrialantioxidantotc
8.1 / 10
Tier A-
Ev 8.0 Bn 6.5 Sf 9.0 Ax 10.0
What this is
Q-SYMBIO trial: 42% reduction in all-cause mortality in advanced HF. Depleted by statins — consider if statin-induced muscle symptoms. Endogenous levels decline with age.
Mechanism
Electron transport chain cofactor (mitochondrial ATP synthesis); lipid-soluble antioxidant in membranes and LDL
Dose & route
100-300 mg/day; ubiquinol form preferred for older adults (better absorption)
Citations
- https://www.jacc.org/doi/10.1016/j.jchf.2014.06.008
- https://pubmed.ncbi.nlm.nih.gov/25282031/
- https://www.ahajournals.org/doi/pdf/10.1161/circheartfailure.115.002639
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