Agmatine sulfate
Cognitive · Neuromodulator (decarboxylated arginine)
Tier C
Bottom line
Read Off Label grades Agmatine sulfate as C (4.9/10) based on weak evidence, med benefit magnitude, and a low-med-risk safety profile.
Keynan 2010 MDD open-label showed response.
Typical use: 1-3 g/day PO divided, empty stomach — OTC.
What this is
Keynan 2010 MDD open-label showed response. Limited controlled human trials. Stacks often include for neuropathic pain and mood. Stomach upset common — take on empty stomach or with minimal food.
Mechanism
Endogenous neuromodulator; imidazoline I1/I2 receptor agonist; NMDA antagonism; nitric oxide synthase inhibition; proposed mood/anxiety and neuropathic pain effects
Dose & route
1-3 g/day PO divided, empty stomach
Citations
- https://pubmed.ncbi.nlm.nih.gov/20303945/
- https://pubmed.ncbi.nlm.nih.gov/23467428/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6165963/
- https://pubmed.ncbi.nlm.nih.gov/18273661/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does Agmatine sulfate work?
- Read Off Label rates the evidence for Agmatine sulfate as Weak and the benefit magnitude as med, producing an overall grade of C (4.9/10). Keynan 2010 MDD open-label showed response.
- Is Agmatine sulfate safe?
- Agmatine sulfate has a low-med risk profile in published human data. Legal status: OTC. This is not medical advice — see the disclaimer.
- What is the typical dose for Agmatine sulfate?
- 1-3 g/day PO divided, empty stomach
- How does Agmatine sulfate work?
- Endogenous neuromodulator; imidazoline I1/I2 receptor agonist; NMDA antagonism; nitric oxide synthase inhibition; proposed mood/anxiety and neuropathic pain effects
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.