Rankings / Cognitive — Nootropics
Agmatine sulfate
Cognitive · Neuromodulator (decarboxylated arginine)
Tier C+
What this is
Keynan 2010 MDD open-label showed response. Limited controlled human trials. Stacks often include for neuropathic pain and mood. Stomach upset common — take on empty stomach or with minimal food.
Mechanism
Endogenous neuromodulator; imidazoline I1/I2 receptor agonist; NMDA antagonism; nitric oxide synthase inhibition; proposed mood/anxiety and neuropathic pain effects
Dose & route
1-3 g/day PO divided, empty stomach
Citations
- https://pubmed.ncbi.nlm.nih.gov/20303945/
- https://pubmed.ncbi.nlm.nih.gov/23467428/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6165963/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.