Anastrozole
Hormones · Aromatase inhibitor
Tier B-
What this is
Vastly overused in TRT practice. Most men on standard TRT doses don't need AI; chronic AI at high doses causes iatrogenic low estradiol symptoms often misattributed to other causes. Only intervene if gyno, edema, or severe mood issues develop AND estradiol is clearly elevated.
Mechanism
Selective non-steroidal aromatase inhibitor; blocks conversion of androgens to estradiol; approved for ER+ breast cancer; off-label for estrogen management during TRT or AAS cycles
Dose & route
0.25-0.5 mg 2x/week for TRT users (cautious dosing); breast cancer 1 mg/day
Citations
- https://pubmed.ncbi.nlm.nih.gov/21353144/
- https://pubmed.ncbi.nlm.nih.gov/22791097/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4155622/
Links go to the source. If a link is dead or you want something re-checked, let me know.
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.