Rankings / Cognitive — Nootropics
Aniracetam
Cognitive · Racetam
Tier C+
What this is
Short plasma half-life (~1-2.5 hr) but active metabolites (N-anisoyl-GABA) may persist. Anecdotal reports of reduced anxiety and improved verbal fluency. Much less studied than piracetam in rigorous modern trials.
Mechanism
Positive allosteric modulator of AMPA receptors (slows desensitization); also cholinergic and serotonergic/dopaminergic modulation; fat-soluble unlike piracetam
Dose & route
750-1500 mg/day PO with fat, divided doses
Citations
- https://pubmed.ncbi.nlm.nih.gov/11346374/
- https://pubmed.ncbi.nlm.nih.gov/11607047/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3648782/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.