Atomoxetine

Cognitive · Selective NRI

Tier B-

dopamineprescription

6.3 / 10

Tier B-

Ev 8.0 Bn 5.0 Sf 5.0 Ax 6.0

What this is

Full effect takes 4-8 weeks. Moderate effect size in ADHD — smaller than stimulants on average. Preferred when stimulants contraindicated or there's comorbid anxiety/substance use. Not a DEA-scheduled drug.

Mechanism

Selective norepinephrine reuptake inhibitor; also increases PFC dopamine (NET clears DA in frontal cortex); non-stimulant; no abuse potential

Dose & route

40-100 mg PO daily

Citations

https://pubmed.ncbi.nlm.nih.gov/18991866/
https://pubmed.ncbi.nlm.nih.gov/26861694/
https://pmc.ncbi.nlm.nih.gov/articles/PMC2695569/

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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.