Rankings / Cognitive — Nootropics
Cerebrolysin
Cognitive · Neurotrophic peptide mix
Tier B-
What this is
CARS trials and meta-analyses show modest functional benefits in acute ischemic stroke when started early. Also some data for vascular dementia and TBI. Multi-component biologic — quality control and batch variability are concerns.
Mechanism
Porcine brain-derived peptide mixture; mimics endogenous neurotrophic factors; BDNF-like activity; used in Europe/Asia for stroke and dementia
Dose & route
10-30 mL IV/IM daily for 10-21 day courses
Citations
- https://pubmed.ncbi.nlm.nih.gov/25768343/
- https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD007026.pub5/full
- https://pubmed.ncbi.nlm.nih.gov/34050760/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.