Rankings / Cognitive — Nootropics
Choline bitartrate
Cognitive · Choline precursor
Tier C-
What this is
Cheap but largely ineffective as a brain-targeted nootropic — poorly crosses BBB. Primarily useful to meet daily choline adequate intake (550 mg men / 425 mg women) if diet is low in eggs/liver. Most 'racetam stacks' that use this are suboptimal vs Alpha-GPC/CDP-choline.
Mechanism
Basic choline salt; poor BBB penetration compared to Alpha-GPC/CDP-choline; mostly useful as peripheral choline source for phosphatidylcholine synthesis
Dose & route
500-2000 mg/day PO
Citations
- https://pubmed.ncbi.nlm.nih.gov/6837754/
- https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/
- https://pubmed.ncbi.nlm.nih.gov/20861172/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.