Rankings / Cognitive — Nootropics
CILTEP (forskolin + artichoke extract)
Cognitive · Stack — cAMP/PDE4
Tier C+
What this is
Invented by Abelard Lindsay (Natural Stacks). Never tested as a combined product in controlled trials. Individual mechanism grounding in Tim Tully's memory consolidation work is real; translation to human cognition untested. Popular in 'classic nootropic' community.
Mechanism
Forskolin activates adenylyl cyclase (cAMP elevation); artichoke extract luteolin inhibits PDE4 (cAMP breakdown); combined effect targets CREB-mediated long-term potentiation
Dose & route
Forskolin 20% 20 mg + artichoke extract 5% luteolin 900 mg, morning, empty stomach
Citations
- https://pubmed.ncbi.nlm.nih.gov/19948975/
- https://pubmed.ncbi.nlm.nih.gov/20028229/
- https://pubmed.ncbi.nlm.nih.gov/21044695/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.