What does the evidence show about CILTEP (forskolin + artichoke extract)'s effects?

Read Off Label rates the evidence for CILTEP (forskolin + artichoke extract) as Weak and the benefit magnitude as variable, producing an overall grade of C (4.9/10). Invented by Abelard Lindsay (Natural Stacks).

What safety findings are reported for CILTEP (forskolin + artichoke extract)?

CILTEP (forskolin + artichoke extract) has a low-med risk profile in the database. Low-Med (forskolin — hypotension, GI; PDE4 inhibition — nausea) Legal status: OTC (individual components).

What doses or routes are reported for CILTEP (forskolin + artichoke extract)?

Forskolin 20% 20 mg + artichoke extract 5% luteolin 900 mg, morning, empty stomach This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.

Rankings / Cognitive

CILTEP (forskolin + artichoke extract)

Cognitive · Stack — cAMP/PDE4

Tier C

Reviewed by Read Off Label · Last reviewed Jun 8, 2026 · How we grade

otc

4.9 / 10

Tier C

Ev 3 Bn 5 Sf 7

Bottom line

Read Off Label grades CILTEP (forskolin + artichoke extract) as C (4.9/10) based on weak evidence, variable benefit magnitude, and a low-med-risk safety profile.

Invented by Abelard Lindsay (Natural Stacks).

Studied, labeled, or reported-use context: Forskolin 20% 20 mg + artichoke extract 5% luteolin 900 mg, morning, empty stomach — OTC; not individualized guidance.

What the evidence says

Invented by Abelard Lindsay (Natural Stacks). Never tested as a combined product in controlled trials. Individual mechanism grounding in Tim Tully's memory consolidation work is real; translation to human cognition untested. Popular in 'classic nootropic' community.

Mechanism

Forskolin activates adenylyl cyclase (cAMP elevation); artichoke extract luteolin inhibits PDE4 (cAMP breakdown); combined effect targets CREB-mediated long-term potentiation

Studied, labeled, or reported dose & route

Forskolin 20% 20 mg + artichoke extract 5% luteolin 900 mg, morning, empty stomach

This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.

Citations

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Common questions

What does the evidence show about CILTEP (forskolin + artichoke extract)'s effects?: Read Off Label rates the evidence for CILTEP (forskolin + artichoke extract) as Weak and the benefit magnitude as variable, producing an overall grade of C (4.9/10). Invented by Abelard Lindsay (Natural Stacks).
What safety findings are reported for CILTEP (forskolin + artichoke extract)?: CILTEP (forskolin + artichoke extract) has a low-med risk profile in the database. Low-Med (forskolin — hypotension, GI; PDE4 inhibition — nausea) Legal status: OTC (individual components).
What doses or routes are reported for CILTEP (forskolin + artichoke extract)?: Forskolin 20% 20 mg + artichoke extract 5% luteolin 900 mg, morning, empty stomach This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
How does CILTEP (forskolin + artichoke extract) work?: Forskolin activates adenylyl cyclase (cAMP elevation); artichoke extract luteolin inhibits PDE4 (cAMP breakdown); combined effect targets CREB-mediated long-term potentiation

This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.