Rankings / Cognitive — Nootropics
Coluracetam (MKC-231)
Cognitive · Racetam
Tier C
What this is
BrainCells Inc/BioLineRx abandoned clinical development after Ph2a did not meet primary endpoint. Reported visual/perceptual effects (enhanced color, contrast) — novel among racetams. Very limited human data.
Mechanism
High-affinity choline uptake enhancer (HACU) — restores choline uptake in damaged neurons; investigated for depression/anxiety and retinal neuroprotection
Dose & route
3-35 mg sublingual or PO; doses highly anecdotal
Citations
- https://pubmed.ncbi.nlm.nih.gov/17182138/
- https://pubmed.ncbi.nlm.nih.gov/17570511/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3648782/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.