Coluracetam (MKC-231)
Cognitive · Racetam
Tier C+
Bottom line
Read Off Label grades Coluracetam (MKC-231) as C+ (5.7/10) based on weak evidence, variable benefit magnitude, and a low-risk safety profile.
BrainCells Inc/BioLineRx abandoned clinical development after Ph2a did not meet primary endpoint.
Studied, labeled, or reported-use context: 3-35 mg sublingual or PO; doses highly anecdotal — Research chem; not individualized guidance.
What the evidence says
BrainCells Inc/BioLineRx abandoned clinical development after Ph2a did not meet primary endpoint. Reported visual/perceptual effects (enhanced color, contrast) — novel among racetams. Very limited human data.
Mechanism
High-affinity choline uptake enhancer (HACU) — restores choline uptake in damaged neurons; investigated for depression/anxiety and retinal neuroprotection
Studied, labeled, or reported dose & route
3-35 mg sublingual or PO; doses highly anecdotal
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Coluracetam (MKC-231)'s effects?
- Read Off Label rates the evidence for Coluracetam (MKC-231) as Weak and the benefit magnitude as variable, producing an overall grade of C+ (5.7/10). BrainCells Inc/BioLineRx abandoned clinical development after Ph2a did not meet primary endpoint.
- What safety findings are reported for Coluracetam (MKC-231)?
- Coluracetam (MKC-231) has a low risk profile in the database. Low (limited data) Legal status: Research chem.
- What doses or routes are reported for Coluracetam (MKC-231)?
- 3-35 mg sublingual or PO; doses highly anecdotal This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Coluracetam (MKC-231) work?
- High-affinity choline uptake enhancer (HACU) — restores choline uptake in damaged neurons; investigated for depression/anxiety and retinal neuroprotection
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.