Rankings / Longevity — Peptides
SS-31 (elamipretide)
Longevity · Mitochondrial peptide
Tier B-
What this is
Specifically targets dysfunctional mitochondria — novel MOA. Promising data in primary mitochondrial myopathy and heart failure with preserved EF. Not yet FDA approved. Represents emerging mitochondria-targeted therapeutic class.
Mechanism
Tetrapeptide that selectively targets cardiolipin in inner mitochondrial membrane; stabilizes cristae; reduces ROS; improves ETC efficiency
Dose & route
40 mg SC daily in Phase 2/3 trials
Citations
- https://pubmed.ncbi.nlm.nih.gov/33876242/
- https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.050756
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7292817/
Links go to the source. If a link is dead or you want something re-checked, let me know.
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.