Rankings / Longevity — Supplements
Urolithin A
Longevity · Mitophagy inducer
Tier B+
What this is
Andreux 2019 first-in-human safety trial. Singh 2022 Cell Reports Med: ~12% muscle strength improvement in middle-aged adults over 4 months. Only 30-40% of humans produce UA from ellagitannins naturally — supplementation bypasses microbial variability.
Mechanism
Gut microbiome metabolite of ellagitannins (pomegranate, walnuts); induces mitophagy — selective autophagy of damaged mitochondria; improves mitochondrial function
Dose & route
500-1000 mg/day
Citations
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9133463/
- https://pubmed.ncbi.nlm.nih.gov/32694802/
- https://www.nature.com/articles/s43587-025-00996-x
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.