Rankings / Cognitive — Nootropics
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide)
Cognitive · HGF/c-Met activator
Tier D+
What this is
Harding lab at WSU developed as Alzheimer's candidate. Claimed enormous potency (picomolar). Never reached human trials. HGF/c-Met pathway activation raises cancer concerns for chronic use. Popular in 'exotic nootropic' circles.
Mechanism
Angiotensin IV analog; potent hepatocyte growth factor (HGF) mimetic; activates c-Met receptor; proposed to promote synaptogenesis/dendritic spine formation
Dose & route
No established human dosing
Citations
- https://pubmed.ncbi.nlm.nih.gov/22297356/
- https://pubmed.ncbi.nlm.nih.gov/29432784/
- https://patents.google.com/patent/US8598118B2/en
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