Rankings / Cognitive — Nootropics
DSIP (delta sleep-inducing peptide)
Cognitive · Neuropeptide
Tier C
What this is
First characterized Monnier 1977. Despite the name, not reliably sleep-inducing in controlled studies. Popular in peptide community for sleep/recovery; evidence is thin. Short plasma half-life.
Mechanism
Nonapeptide isolated from rabbit brain dialysate during delta sleep; proposed sleep modulatory and stress-protective effects; mechanism unclear
Dose & route
100-500 mcg subQ at night (anecdotal)
Citations
- https://pubmed.ncbi.nlm.nih.gov/6392441/
- https://pubmed.ncbi.nlm.nih.gov/3797927/
- https://pubmed.ncbi.nlm.nih.gov/2657552/
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