Rankings / Hormones & Endocrine
Enclomiphene citrate
Hormones & Endocrine · SERM (HPG restart)
Tier B-
What this is
Cleaner pharmacology than mixed clomiphene because it lacks zuclomiphene, the longer-lived estrogenic isomer. Phase 2/3 studies showed testosterone restoration while maintaining sperm counts, unlike testosterone gel. FDA did not approve Androxal after the 2015 review cycle, so US access is compounded or research-market rather than an approved product. Hohl 2025 grouped clomiphene and enclomiphene SERMs and found higher TT, LH, and FSH versus placebo; do not treat that as proof of identical risk.
Mechanism
Trans isomer of clomiphene; estrogen receptor antagonist at hypothalamus/pituitary; raises GnRH → LH/FSH → endogenous testosterone while preserving spermatogenesis in secondary hypogonadism
Dose & route
12.5-25 mg/day PO in trials and common compounded protocols
Citations
- https://pubmed.ncbi.nlm.nih.gov/41066380/
- https://pubmed.ncbi.nlm.nih.gov/27226163/
- https://pubmed.ncbi.nlm.nih.gov/23253627/
- https://www.drugs.com/history/androxal.html
- https://www.fda.gov/media/159043/download
Links go to the source. If a link is dead or you want something re-checked, let me know.
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.