Fadogia agrestis
Libido · Nigerian shrub
Tier C-
What this is
Virtually no human data. Single Yakubu 2005 rat study — which also documented testicular and hepatic toxicity at higher doses — is the foundation of the entire supplement category. Popularity driven by Huberman Lab podcast discussion. Often stacked with tongkat ali despite absence of evidence for either combination or individual efficacy in humans.
Mechanism
Crude extract from Fadogia agrestis stem; proposed LH stimulation and testosterone increase based on a single 2005 rat study (Yakubu); no published human trials
Dose & route
Typical marketing dose 600 mg/day
Citations
- https://pubmed.ncbi.nlm.nih.gov/15945625/
- https://pubmed.ncbi.nlm.nih.gov/16425061/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7824101/
Links go to the source. If a link is dead or you want something re-checked, let me know.
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.