Does Fadogia agrestis work?

Read Off Label rates the evidence for Fadogia agrestis as None and the benefit magnitude as unclear, producing an overall grade of F (2.0/10). Virtually no human data.

Is Fadogia agrestis safe?

Fadogia agrestis has a unknown-high risk profile in published human data. Legal status: OTC (supplement). This is not medical advice — see the disclaimer.

Rankings / Hormones & Endocrine

Fadogia agrestis

Hormones & Endocrine · Nigerian shrub

Tier F

Reviewed by Read Off Label · Last reviewed Jun 7, 2026 · How we grade

otcweak-evidence

2 / 10

Tier F

Ev 0 Bn 5 Sf 3

Bottom line

Read Off Label grades Fadogia agrestis as F (2.0/10) based on none evidence, unclear benefit magnitude, and a unknown-high-risk safety profile.

Virtually no human data.

Typical use: Typical marketing dose 600 mg/day — OTC.

What this is

Virtually no human data. Single Yakubu 2005 rat study — which also documented testicular and hepatic toxicity at higher doses — is the foundation of the entire supplement category. Popularity driven by Huberman Lab podcast discussion. Often stacked with tongkat ali despite absence of evidence for either combination or individual efficacy in humans.

Mechanism

Crude extract from Fadogia agrestis stem; proposed LH stimulation and testosterone increase based on a single 2005 rat study (Yakubu); no published human trials

Dose & route

Typical marketing dose 600 mg/day

Citations

Links go to the source. If a link is dead or you want something re-checked, let me know.

Common questions

Does Fadogia agrestis work?: Read Off Label rates the evidence for Fadogia agrestis as None and the benefit magnitude as unclear, producing an overall grade of F (2.0/10). Virtually no human data.
Is Fadogia agrestis safe?: Fadogia agrestis has a unknown-high risk profile in published human data. Legal status: OTC (supplement). This is not medical advice — see the disclaimer.
What is the typical dose for Fadogia agrestis?: Typical marketing dose 600 mg/day
How does Fadogia agrestis work?: Crude extract from Fadogia agrestis stem; proposed LH stimulation and testosterone increase based on a single 2005 rat study (Yakubu); no published human trials

This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.