Rankings / Cognitive — Nootropics
Fasoracetam
Cognitive · Racetam
Tier C
What this is
Developed by Nippon Shinyaku; acquired by Aevi Medical then Supernus. Phase 2 in adolescents with ADHD and mGluR network mutations showed modest effect; Phase 3 program effectively halted. Popular in nootropic circles; limited tolerance.
Mechanism
mGluR (metabotropic glutamate receptor) upregulator — unique among racetams; also GABA-B agonist activity; investigated for ADHD with mGluR gene mutations
Dose & route
20-400 mg/day PO in trials
Citations
- https://pubmed.ncbi.nlm.nih.gov/30353745/
- https://www.sec.gov/Archives/edgar/data/1613780/000121390019001648/f10k2018_aevimedicalinc.htm
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6326837/
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