Fasoracetam
Cognitive · Racetam
Tier C+
Bottom line
Read Off Label grades Fasoracetam as C+ (5.7/10) based on weak evidence, variable benefit magnitude, and a low-risk safety profile.
Developed by Nippon Shinyaku; acquired by Aevi Medical then Supernus.
Studied, labeled, or reported-use context: 20-400 mg/day PO in trials — Research chem; formerly investigational drug; not individualized guidance.
What the evidence says
Developed by Nippon Shinyaku; acquired by Aevi Medical then Supernus. Phase 2 in adolescents with ADHD and mGluR network mutations showed modest effect; Phase 3 program effectively halted. Popular in nootropic circles; limited tolerance.
Mechanism
mGluR (metabotropic glutamate receptor) upregulator — unique among racetams; also GABA-B agonist activity; investigated for ADHD with mGluR gene mutations
Studied, labeled, or reported dose & route
20-400 mg/day PO in trials
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Fasoracetam's effects?
- Read Off Label rates the evidence for Fasoracetam as Weak and the benefit magnitude as variable, producing an overall grade of C+ (5.7/10). Developed by Nippon Shinyaku; acquired by Aevi Medical then Supernus.
- What safety findings are reported for Fasoracetam?
- Fasoracetam has a low risk profile in the database. Low (reported in trials) Legal status: Research chem; formerly investigational drug.
- What doses or routes are reported for Fasoracetam?
- 20-400 mg/day PO in trials This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Fasoracetam work?
- mGluR (metabotropic glutamate receptor) upregulator — unique among racetams; also GABA-B agonist activity; investigated for ADHD with mGluR gene mutations
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.