Rankings / Cognitive — Nootropics
Huperzine A
Cognitive · AChE inhibitor (natural)
Tier B-
What this is
Extensively studied in China for AD/MCI. Long duration of AChE inhibition (~24 hr) means cycling recommended to prevent tolerance and cholinergic side effects. Should not stack with prescription AChE inhibitors (donepezil, etc).
Mechanism
Reversible, selective acetylcholinesterase inhibitor from Chinese club moss (Huperzia serrata); also NMDA antagonist and neuroprotective activity
Dose & route
50-400 mcg/day PO; cycling common
Citations
- https://pubmed.ncbi.nlm.nih.gov/23543923/
- https://pubmed.ncbi.nlm.nih.gov/18841458/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4961898/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.