What does the evidence show about Kisspeptin-10's effects?

Read Off Label rates the evidence for Kisspeptin-10 as Weak-Moderate and the benefit magnitude as low-med, producing an overall grade of B- (6.2/10). Imperial College Waljit Dhillo group has pioneered kisspeptin as a sexual-function and fertility therapeutic.

What safety findings are reported for Kisspeptin-10?

Kisspeptin-10 has a low risk profile in the database. Low (well-tolerated in trials); Unknown long-term Legal status: Research peptide; not FDA-approved.

Rankings / Hormones & Endocrine

Kisspeptin-10

Hormones & Endocrine · Hypothalamic peptide

Tier B-

Reviewed by Read Off Label · Last reviewed Jul 23, 2026 · How we grade

peptidegnrh-axis

6.2 / 10

Tier B-

Ev 4.5 Bn 3.5 Sf 9

Bottom line

Read Off Label grades Kisspeptin-10 as B- (6.2/10) based on weak-moderate evidence, low-med benefit magnitude, and a low-risk safety profile.

Imperial College Waljit Dhillo group has pioneered kisspeptin as a sexual-function and fertility therapeutic.

Studied, labeled, or reported-use context: 1-3 mcg/kg subQ or IV bolus in trials — Research peptide; not FDA-approved; not individualized guidance.

What the evidence says

Imperial College Waljit Dhillo group has pioneered kisspeptin as a sexual-function and fertility therapeutic. Thurston 2022 showed increased sexual brain activation in HSDD women. Not the same as MKC-231/coluracetam despite similar names. Research-stage peptide with emerging human data.

Mechanism

Endogenous KISS1-gene product; binds KISS1R (GPR54) on GnRH neurons; master regulator of GnRH/LH/FSH pulsatility; proposed for HSDD, hypothalamic amenorrhea, fertility

Studied, labeled, or reported dose & route

1-3 mcg/kg subQ or IV bolus in trials

This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.

Citations

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Common questions

What does the evidence show about Kisspeptin-10's effects?: Read Off Label rates the evidence for Kisspeptin-10 as Weak-Moderate and the benefit magnitude as low-med, producing an overall grade of B- (6.2/10). Imperial College Waljit Dhillo group has pioneered kisspeptin as a sexual-function and fertility therapeutic.
What safety findings are reported for Kisspeptin-10?: Kisspeptin-10 has a low risk profile in the database. Low (well-tolerated in trials); Unknown long-term Legal status: Research peptide; not FDA-approved.
What doses or routes are reported for Kisspeptin-10?: 1-3 mcg/kg subQ or IV bolus in trials This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
How does Kisspeptin-10 work?: Endogenous KISS1-gene product; binds KISS1R (GPR54) on GnRH neurons; master regulator of GnRH/LH/FSH pulsatility; proposed for HSDD, hypothalamic amenorrhea, fertility

This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.