Does Kisspeptin-10 work?

Read Off Label rates the evidence for Kisspeptin-10 as Weak-Moderate and the benefit magnitude as low-med, producing an overall grade of B- (6.2/10). Imperial College Waljit Dhillo group has pioneered kisspeptin as a sexual-function and fertility therapeutic.

Is Kisspeptin-10 safe?

Kisspeptin-10 has a low risk profile in published human data. Legal status: Research peptide; not FDA-approved. This is not medical advice — see the disclaimer.

Rankings / Hormones & Endocrine

Kisspeptin-10

Hormones & Endocrine · Hypothalamic peptide

Tier B-

Reviewed by Read Off Label · Last reviewed Jun 7, 2026 · How we grade

peptidegnrh-axis

6.2 / 10

Tier B-

Ev 4.5 Bn 3.5 Sf 9

Bottom line

Read Off Label grades Kisspeptin-10 as B- (6.2/10) based on weak-moderate evidence, low-med benefit magnitude, and a low-risk safety profile.

Imperial College Waljit Dhillo group has pioneered kisspeptin as a sexual-function and fertility therapeutic.

Typical use: 1-3 mcg/kg subQ or IV bolus in trials — Research peptide; not FDA-approved.

What this is

Imperial College Waljit Dhillo group has pioneered kisspeptin as a sexual-function and fertility therapeutic. Thurston 2022 showed increased sexual brain activation in HSDD women. Not the same as MKC-231/coluracetam despite similar names. Research-stage peptide with emerging human data.

Mechanism

Endogenous KISS1-gene product; binds KISS1R (GPR54) on GnRH neurons; master regulator of GnRH/LH/FSH pulsatility; proposed for HSDD, hypothalamic amenorrhea, fertility

Dose & route

1-3 mcg/kg subQ or IV bolus in trials

Citations

Links go to the source. If a link is dead or you want something re-checked, let me know.

Common questions

Does Kisspeptin-10 work?: Read Off Label rates the evidence for Kisspeptin-10 as Weak-Moderate and the benefit magnitude as low-med, producing an overall grade of B- (6.2/10). Imperial College Waljit Dhillo group has pioneered kisspeptin as a sexual-function and fertility therapeutic.
Is Kisspeptin-10 safe?: Kisspeptin-10 has a low risk profile in published human data. Legal status: Research peptide; not FDA-approved. This is not medical advice — see the disclaimer.
What is the typical dose for Kisspeptin-10?: 1-3 mcg/kg subQ or IV bolus in trials
How does Kisspeptin-10 work?: Endogenous KISS1-gene product; binds KISS1R (GPR54) on GnRH neurons; master regulator of GnRH/LH/FSH pulsatility; proposed for HSDD, hypothalamic amenorrhea, fertility

This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.