Melanotan II (MT-II)
Libido · Non-selective melanocortin agonist
Tier C
What this is
Popular for simultaneous tanning + sexual function effect. Mole darkening case reports and at least several melanoma case reports raise concern — not causation-established but concerning in people with dysplastic nevi. Counterfeit/underdosed products widespread.
Mechanism
Non-selective melanocortin receptor agonist (MC1R/3R/4R/5R); MC1R activation induces tanning (melanogenesis); MC4R activation drives libido/erection; never FDA-approved for any use
Dose & route
0.25-1 mg subQ per dose (highly individual tolerance)
Citations
- https://pubmed.ncbi.nlm.nih.gov/9609743/
- https://pubmed.ncbi.nlm.nih.gov/19558395/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC2656445/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.