Oxiracetam
Cognitive · Racetam
Tier B
Bottom line
Read Off Label grades Oxiracetam as B (6.4/10) based on weak-moderate evidence, variable benefit magnitude, and a low-risk safety profile.
Italian/Chinese clinical use for multi-infarct dementia.
Typical use: 1200-2400 mg/day PO divided — Rx in Italy/China; research chem in US.
What this is
Italian/Chinese clinical use for multi-infarct dementia. Fewer side effects than piracetam reported. More stimulating profile — users sometimes dose only in the morning.
Mechanism
Structural analog of piracetam with additional hydroxyl group; enhances acetylcholine release; AMPA-positive modulation; described as mildly stimulating
Dose & route
1200-2400 mg/day PO divided
Citations
- https://pubmed.ncbi.nlm.nih.gov/1521674/
- https://pubmed.ncbi.nlm.nih.gov/2675146/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3648782/
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Common questions
- Does Oxiracetam work?
- Read Off Label rates the evidence for Oxiracetam as Weak-Moderate and the benefit magnitude as variable, producing an overall grade of B (6.4/10). Italian/Chinese clinical use for multi-infarct dementia.
- Is Oxiracetam safe?
- Oxiracetam has a low risk profile in published human data. Legal status: Rx in Italy/China; research chem in US. This is not medical advice — see the disclaimer.
- What is the typical dose for Oxiracetam?
- 1200-2400 mg/day PO divided
- How does Oxiracetam work?
- Structural analog of piracetam with additional hydroxyl group; enhances acetylcholine release; AMPA-positive modulation; described as mildly stimulating
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.