Rankings / Cognitive — Nootropics
P21 peptide
Cognitive · Peptide (CNTF analog)
Tier D+
What this is
Derived from Iqbal lab work at NYS Institute for Basic Research. Preclinical mouse data on learning and neurogenesis. No published human trials. Sold by gray-market peptide vendors despite minimal evidence.
Mechanism
Synthetic 4-amino-acid peptide derived from ciliary neurotrophic factor (CNTF); proposed to stimulate neurogenesis via CNTF receptor pathway
Dose & route
No established human dosing
Citations
- https://pubmed.ncbi.nlm.nih.gov/23566962/
- https://pubmed.ncbi.nlm.nih.gov/24721664/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4275686/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.