P21 peptide
Cognitive · Peptide (CNTF analog)
Tier D
Bottom line
Read Off Label grades P21 peptide as D (3.3/10) based on preclinical only evidence, unclear benefit magnitude, and a unclear-risk safety profile.
Derived from Iqbal lab work at NYS Institute for Basic Research.
Typical use: No established human dosing — Research chem.
What this is
Derived from Iqbal lab work at NYS Institute for Basic Research. Preclinical mouse data on learning and neurogenesis. No published human trials. Sold by gray-market peptide vendors despite minimal evidence.
Mechanism
Synthetic 4-amino-acid peptide derived from ciliary neurotrophic factor (CNTF); proposed to stimulate neurogenesis via CNTF receptor pathway
Dose & route
No established human dosing
Citations
- https://pubmed.ncbi.nlm.nih.gov/23566962/
- https://pubmed.ncbi.nlm.nih.gov/24721664/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4275686/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does P21 peptide work?
- Read Off Label rates the evidence for P21 peptide as Preclinical only and the benefit magnitude as unclear, producing an overall grade of D (3.3/10). Derived from Iqbal lab work at NYS Institute for Basic Research.
- Is P21 peptide safe?
- P21 peptide has a unclear risk profile in published human data. Legal status: Research chem. This is not medical advice — see the disclaimer.
- What is the typical dose for P21 peptide?
- No established human dosing
- How does P21 peptide work?
- Synthetic 4-amino-acid peptide derived from ciliary neurotrophic factor (CNTF); proposed to stimulate neurogenesis via CNTF receptor pathway
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.