Rankings / Cognitive — Nootropics
Phosphatidylserine
Cognitive · Membrane phospholipid
Tier B
What this is
Originally from bovine brain (prion concerns retired that source); current products from soy or sunflower lecithin. Starks 2008 showed reduced cortisol response to physical stress. Good adjunct in age-related cognitive complaints.
Mechanism
Major acidic phospholipid in neuronal membranes; supports membrane fluidity, receptor density, neurotransmitter release; blunts cortisol response to stress
Dose & route
100-300 mg/day PO
Citations
- https://pubmed.ncbi.nlm.nih.gov/25933483/
- https://pubmed.ncbi.nlm.nih.gov/18662395/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4818998/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.