Phosphatidylserine
Cognitive · Membrane phospholipid
Tier B+
Bottom line
Read Off Label grades Phosphatidylserine as B+ (7.1/10) based on moderate evidence, med benefit magnitude, and a low-risk safety profile.
Originally from bovine brain (prion concerns retired that source); current products from soy or sunflower lecithin.
Studied, labeled, or reported-use context: 100-300 mg/day PO — OTC; not individualized guidance.
What the evidence says
Originally from bovine brain (prion concerns retired that source); current products from soy or sunflower lecithin. Starks 2008 showed reduced cortisol response to physical stress. Small studies report outcomes in age-related cognitive complaints; evidence is rated Moderate in this entry.
Mechanism
Major acidic phospholipid in neuronal membranes; supports membrane fluidity, receptor density, neurotransmitter release; blunts cortisol response to stress
Studied, labeled, or reported dose & route
100-300 mg/day PO
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Phosphatidylserine's effects?
- Read Off Label rates the evidence for Phosphatidylserine as Moderate and the benefit magnitude as med, producing an overall grade of B+ (7.1/10). Originally from bovine brain (prion concerns retired that source); current products from soy or sunflower lecithin.
- What safety findings are reported for Phosphatidylserine?
- Phosphatidylserine has a low risk profile in the database. Low (GI upset) Legal status: OTC.
- What doses or routes are reported for Phosphatidylserine?
- 100-300 mg/day PO This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Phosphatidylserine work?
- Major acidic phospholipid in neuronal membranes; supports membrane fluidity, receptor density, neurotransmitter release; blunts cortisol response to stress
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.