Rankings / Cognitive — Nootropics
Pramiracetam
Cognitive · Racetam
Tier C
What this is
Most potent racetam by dose. 1990s trials in TBI and AD showed modest signals but never pursued to approval. Users commonly report 'memory formation' effects. Very limited modern data. Requires choline co-administration per nootropic lore.
Mechanism
High-affinity choline uptake enhancer (HACU); increases hippocampal ACh synthesis; no direct receptor binding; fat-soluble
Dose & route
400-1200 mg/day PO divided, with fat
Citations
- https://pubmed.ncbi.nlm.nih.gov/1844174/
- https://pubmed.ncbi.nlm.nih.gov/8061686/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3648782/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.