Rankings / Cognitive — Nootropics
PRL-8-53
Cognitive · Obscure nootropic
Tier D+
What this is
Synthesized by Nikolaus Hansl at Creighton in the 1970s. The single human paper reported striking verbal memory improvement but was never replicated in 40+ years. Exemplar of a 'forgotten nootropic' with folkloric reputation and no modern data.
Mechanism
Benzhydryl-based compound; proposed cholinergic and dopaminergic potentiation; mechanism poorly characterized
Dose & route
No established modern dosing
Citations
- https://pubmed.ncbi.nlm.nih.gov/686364/
- https://patents.google.com/patent/US3870719A/en
- https://pubmed.ncbi.nlm.nih.gov/693019/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.