PT-141 (Bremelanotide / Vyleesi)
Libido · Melanocortin receptor agonist
Tier C+
What this is
AMAG Pharma's approval came with significant Rx uptake challenges — nausea is common. Off-label use in men for 'libido enhancement' popular in biohacker circles despite not being formally studied. Shares MC1R activity with Melanotan II — some tanning/darkening with repeated use.
Mechanism
Cyclic heptapeptide; non-selective melanocortin receptor agonist (MC3R, MC4R most relevant for sexual function); acts centrally to increase sexual desire; FDA-approved for premenopausal HSDD in women
Dose & route
1.75 mg subQ 45 min before sexual activity; max 8 doses/month
Citations
- https://pubmed.ncbi.nlm.nih.gov/31483222/
- https://pubmed.ncbi.nlm.nih.gov/32030885/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7379117/
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