Rankings / Hormones & Endocrine
Pyrilutamide (KX-826)
Hormones & Endocrine · Topical androgen receptor antagonist
Tier C
Bottom line
Read Off Label grades Pyrilutamide (KX-826) as C (4.9/10) based on weak evidence, med benefit magnitude, and a low-med-risk safety profile.
Kintor Pharmaceutical.
Typical use: Topical, applied to scalp twice daily — Investigational.
What this is
Kintor Pharmaceutical. Topical AR antagonist for AGA: China Phase 3 ongoing; US Phase 2 results mixed (inconsistent primary endpoints), Phase 3 design under revision. Mechanistically similar to topical clascoterone. Industry-sponsored; not yet conclusive.
Mechanism
Topical androgen-receptor antagonist for androgenetic alopecia, blocking scalp DHT signaling locally to avoid the systemic sexual side effects of oral finasteride/dutasteride.
Dose & route
Topical, applied to scalp twice daily
Citations
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Common questions
- Does Pyrilutamide (KX-826) work?
- Read Off Label rates the evidence for Pyrilutamide (KX-826) as Weak and the benefit magnitude as med, producing an overall grade of C (4.9/10). Kintor Pharmaceutical.
- Is Pyrilutamide (KX-826) safe?
- Pyrilutamide (KX-826) has a low-med risk profile in published human data. Legal status: Investigational (China Phase 3; US Phase 2/3). This is not medical advice — see the disclaimer.
- What is the typical dose for Pyrilutamide (KX-826)?
- Topical, applied to scalp twice daily
- How does Pyrilutamide (KX-826) work?
- Topical androgen-receptor antagonist for androgenetic alopecia, blocking scalp DHT signaling locally to avoid the systemic sexual side effects of oral finasteride/dutasteride.
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.