Selank
Cognitive · Russian peptide
Tier C+
Bottom line
Read Off Label grades Selank as C+ (5.7/10) based on weak evidence, variable benefit magnitude, and a low-risk safety profile.
Claimed to reduce anxiety without the sedation or dependence of benzodiazepines.
Typical use: 300-1500 mcg intranasal daily — Research chemical.
What this is
Claimed to reduce anxiety without the sedation or dependence of benzodiazepines. Russian trials in generalized anxiety disorder. Very limited Western replication. Often stacked with Semax.
Mechanism
Synthetic analog of tuftsin; anxiolytic via GABAergic modulation; increases BDNF; enkephalin modulation — atypical anxiolytic without sedation
Dose & route
300-1500 mcg intranasal daily
Citations
- https://pubmed.ncbi.nlm.nih.gov/19639854/
- https://pubmed.ncbi.nlm.nih.gov/19621276/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7232131/
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Common questions
- Does Selank work?
- Read Off Label rates the evidence for Selank as Weak and the benefit magnitude as variable, producing an overall grade of C+ (5.7/10). Claimed to reduce anxiety without the sedation or dependence of benzodiazepines.
- Is Selank safe?
- Selank has a low risk profile in published human data. Legal status: Research chemical (Russia Rx). This is not medical advice — see the disclaimer.
- What is the typical dose for Selank?
- 300-1500 mcg intranasal daily
- How does Selank work?
- Synthetic analog of tuftsin; anxiolytic via GABAergic modulation; increases BDNF; enkephalin modulation — atypical anxiolytic without sedation
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.