Semax
Cognitive · Russian peptide
Tier C+
Bottom line
Read Off Label grades Semax as C+ (5.7/10) based on weak evidence, variable benefit magnitude, and a low-risk safety profile.
Used in Russia for stroke, ADHD, cognitive support.
Typical use: 200-600 mcg intranasal daily in cycles — Research chemical.
What this is
Used in Russia for stroke, ADHD, cognitive support. Very limited peer-reviewed Western data. Popular in DIY nootropic communities. Some users report focus/mood improvement; others nothing.
Mechanism
Synthetic ACTH(4-10) analog; BDNF/NGF upregulation; dopaminergic/serotonergic modulation; neuroprotective via HPA modulation
Dose & route
200-600 mcg intranasal daily in cycles
Citations
- https://pubmed.ncbi.nlm.nih.gov/21350679/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6767061/
- https://pubmed.ncbi.nlm.nih.gov/18668073/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does Semax work?
- Read Off Label rates the evidence for Semax as Weak and the benefit magnitude as variable, producing an overall grade of C+ (5.7/10). Used in Russia for stroke, ADHD, cognitive support.
- Is Semax safe?
- Semax has a low risk profile in published human data. Legal status: Research chemical (Russia Rx). This is not medical advice — see the disclaimer.
- What is the typical dose for Semax?
- 200-600 mcg intranasal daily in cycles
- How does Semax work?
- Synthetic ACTH(4-10) analog; BDNF/NGF upregulation; dopaminergic/serotonergic modulation; neuroprotective via HPA modulation
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.