Semax

Cognitive · Russian peptide

Tier C

dopaminepeptidebdnfresearch-only

5.0 / 10

Tier C

Ev 3.0 Bn 5.0 Sf 9.0 Ax 3.0

What this is

Used in Russia for stroke, ADHD, cognitive support. Very limited peer-reviewed Western data. Popular in DIY nootropic communities. Some users report focus/mood improvement; others nothing.

Mechanism

Synthetic ACTH(4-10) analog; BDNF/NGF upregulation; dopaminergic/serotonergic modulation; neuroprotective via HPA modulation

Dose & route

200-600 mcg intranasal daily in cycles

Citations

https://pubmed.ncbi.nlm.nih.gov/21350679/
https://pmc.ncbi.nlm.nih.gov/articles/PMC6767061/
https://pubmed.ncbi.nlm.nih.gov/18668073/

Links go to the source. If a link is dead or you want something re-checked, let me know.

This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.