Sulbutiamine
Cognitive · Thiamine derivative
Tier C+
Bottom line
Read Off Label grades Sulbutiamine as C+ (5.7/10) based on weak evidence, med benefit magnitude, and a low-risk safety profile.
Arcalion brand in France, historically used for asthenia/fatigue.
Studied, labeled, or reported-use context: 200-600 mg/day PO — Rx in France; OTC in many countries; not individualized guidance.
What the evidence says
Arcalion brand in France, historically used for asthenia/fatigue. Anecdotally mood-lifting and motivating short-term; tolerance develops rapidly (days to weeks). Cycling appears in consumer protocols; evidence comparing cyclic with chronic use is absent.
Mechanism
Lipophilic disulfide dimer of thiamine (B1); crosses BBB easily; increases thiamine and thiamine phosphate esters in brain; dopaminergic modulation
Studied, labeled, or reported dose & route
200-600 mg/day PO
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Sulbutiamine's effects?
- Read Off Label rates the evidence for Sulbutiamine as Weak and the benefit magnitude as med, producing an overall grade of C+ (5.7/10). Arcalion brand in France, historically used for asthenia/fatigue.
- What safety findings are reported for Sulbutiamine?
- Sulbutiamine has a low risk profile in the database. Low (rare skin reactions; tolerance develops) Legal status: Rx in France; OTC in many countries.
- What doses or routes are reported for Sulbutiamine?
- 200-600 mg/day PO This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Sulbutiamine work?
- Lipophilic disulfide dimer of thiamine (B1); crosses BBB easily; increases thiamine and thiamine phosphate esters in brain; dopaminergic modulation
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.