Rankings / Cognitive — Nootropics
Sunifiram (DM-235)
Cognitive · Ampakine-like
Tier D+
What this is
No human trials. Banned in Japan and possibly other jurisdictions. Sold as research chemical. AMPA PAM activity raises theoretical seizure risk with chronic use. Popular in early 2010s nootropic forums.
Mechanism
Piperazine derivative; positive allosteric modulator of AMPA receptors (similar effect to ampakines); claimed 1000x potency vs piracetam in mouse amnesia models
Dose & route
No established human dosing
Citations
- https://pubmed.ncbi.nlm.nih.gov/11964160/
- https://pubmed.ncbi.nlm.nih.gov/12499064/
- https://pubmed.ncbi.nlm.nih.gov/21777480/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.