Sunifiram (DM-235)
Cognitive · Ampakine-like
Tier D
Bottom line
Read Off Label grades Sunifiram (DM-235) as D (3.3/10) based on preclinical only evidence, unclear benefit magnitude, and a unclear-risk safety profile.
No human trials.
Studied, labeled, or reported-use context: No established human dosing — Research chem; banned in some countries; not individualized guidance.
What the evidence says
No human trials. Banned in Japan and possibly other jurisdictions. Sold as research chemical. AMPA PAM activity raises theoretical seizure risk with chronic use. Popular in early 2010s nootropic forums.
Mechanism
Piperazine derivative; positive allosteric modulator of AMPA receptors (similar effect to ampakines); claimed 1000x potency vs piracetam in mouse amnesia models
Studied, labeled, or reported dose & route
No established human dosing
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Sunifiram (DM-235)'s effects?
- Read Off Label rates the evidence for Sunifiram (DM-235) as Preclinical only and the benefit magnitude as unclear, producing an overall grade of D (3.3/10). No human trials.
- What safety findings are reported for Sunifiram (DM-235)?
- Sunifiram (DM-235) has a unclear risk profile in the database. Unknown (no human safety; seizure risk plausible from AMPA PAM activity) Legal status: Research chem; banned in some countries.
- What doses or routes are reported for Sunifiram (DM-235)?
- No established human dosing This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Sunifiram (DM-235) work?
- Piperazine derivative; positive allosteric modulator of AMPA receptors (similar effect to ampakines); claimed 1000x potency vs piracetam in mouse amnesia models
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.