Uridine monophosphate
Cognitive · Nucleotide / membrane substrate
Tier C+
Bottom line
Read Off Label grades Uridine monophosphate as C+ (5.7/10) based on weak evidence, med benefit magnitude, and a low-risk safety profile.
Wurtman's MIT lab demonstrated that uridine + DHA + choline together dramatically increase synaptic membrane formation (basis of Souvenaid AD medical food).
Studied, labeled, or reported-use context: 150-300 mg/day PO; sublingual to bypass first-pass metabolism — OTC; not individualized guidance.
What the evidence says
Wurtman's MIT lab demonstrated that uridine + DHA + choline together dramatically increase synaptic membrane formation (basis of Souvenaid AD medical food). Standalone effects more modest. Popular in 'social' stack tradition.
Mechanism
Pyrimidine precursor for phosphatidylcholine synthesis via Kennedy pathway; increases synaptic membrane formation; potentiates DHA effects on synaptogenesis
Studied, labeled, or reported dose & route
150-300 mg/day PO; sublingual to bypass first-pass metabolism
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Uridine monophosphate's effects?
- Read Off Label rates the evidence for Uridine monophosphate as Weak and the benefit magnitude as med, producing an overall grade of C+ (5.7/10). Wurtman's MIT lab demonstrated that uridine + DHA + choline together dramatically increase synaptic membrane formation (basis of Souvenaid AD medical food).
- What safety findings are reported for Uridine monophosphate?
- Uridine monophosphate has a low risk profile in the database. Low Legal status: OTC.
- What doses or routes are reported for Uridine monophosphate?
- 150-300 mg/day PO; sublingual to bypass first-pass metabolism This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Uridine monophosphate work?
- Pyrimidine precursor for phosphatidylcholine synthesis via Kennedy pathway; increases synaptic membrane formation; potentiates DHA effects on synaptogenesis
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.