Uridine monophosphate
Cognitive · Nucleotide / membrane substrate
Tier C+
Bottom line
Read Off Label grades Uridine monophosphate as C+ (5.7/10) based on weak evidence, med benefit magnitude, and a low-risk safety profile.
Wurtman's MIT lab demonstrated that uridine + DHA + choline together dramatically increase synaptic membrane formation (basis of Souvenaid AD medical food).
Typical use: 150-300 mg/day PO; sublingual to bypass first-pass metabolism — OTC.
What this is
Wurtman's MIT lab demonstrated that uridine + DHA + choline together dramatically increase synaptic membrane formation (basis of Souvenaid AD medical food). Standalone effects more modest. Popular in 'social' stack tradition.
Mechanism
Pyrimidine precursor for phosphatidylcholine synthesis via Kennedy pathway; increases synaptic membrane formation; potentiates DHA effects on synaptogenesis
Dose & route
150-300 mg/day PO; sublingual to bypass first-pass metabolism
Citations
- https://pubmed.ncbi.nlm.nih.gov/18614717/
- https://pubmed.ncbi.nlm.nih.gov/16027150/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6523628/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does Uridine monophosphate work?
- Read Off Label rates the evidence for Uridine monophosphate as Weak and the benefit magnitude as med, producing an overall grade of C+ (5.7/10). Wurtman's MIT lab demonstrated that uridine + DHA + choline together dramatically increase synaptic membrane formation (basis of Souvenaid AD medical food).
- Is Uridine monophosphate safe?
- Uridine monophosphate has a low risk profile in published human data. Legal status: OTC. This is not medical advice — see the disclaimer.
- What is the typical dose for Uridine monophosphate?
- 150-300 mg/day PO; sublingual to bypass first-pass metabolism
- How does Uridine monophosphate work?
- Pyrimidine precursor for phosphatidylcholine synthesis via Kennedy pathway; increases synaptic membrane formation; potentiates DHA effects on synaptogenesis
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.