Rankings / Cognitive — Nootropics
Uridine monophosphate
Cognitive · Nucleotide / membrane substrate
Tier C+
What this is
Wurtman's MIT lab demonstrated that uridine + DHA + choline together dramatically increase synaptic membrane formation (basis of Souvenaid AD medical food). Standalone effects more modest. Popular in 'social' stack tradition.
Mechanism
Pyrimidine precursor for phosphatidylcholine synthesis via Kennedy pathway; increases synaptic membrane formation; potentiates DHA effects on synaptogenesis
Dose & route
150-300 mg/day PO; sublingual to bypass first-pass metabolism
Citations
- https://pubmed.ncbi.nlm.nih.gov/18614717/
- https://pubmed.ncbi.nlm.nih.gov/16027150/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6523628/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.