Rankings / Weight Loss — Other
Yohimbine
Weight loss · Alpha-2 antagonist
Tier C+
What this is
Works best in lean individuals losing stubborn fat (α2 receptor density). Full stomach blunts effect (insulin blunts lipolysis). Anxiety and hypertension risk is real — start low.
Mechanism
Selective α2-adrenoceptor antagonist; blocks presynaptic α2 autoreceptors — enhances noradrenaline release; increases lipolysis in stubborn fat; also erectile dysfunction use
Dose & route
0.2 mg/kg fasted pre-exercise for fat loss; 5-10 mg for ED
Citations
- https://pubmed.ncbi.nlm.nih.gov/16751570/
- https://pubmed.ncbi.nlm.nih.gov/17214405/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5481049/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.