Rankings / Hormones & Endocrine
Yohimbine
Hormones & Endocrine · Alpha-2 adrenergic antagonist
Tier C
Bottom line
Read Off Label grades Yohimbine as C (4.9/10) based on moderate evidence, moderate benefit magnitude, and a med-high-risk safety profile.
Yohimbine HCl and yohimbe bark are distinct — the latter has unpredictable alkaloid content including rauwolscine.
Typical use: 5-10 mg yohimbine HCl 2-3x/day (fat loss); 10-20 mg PRN (ED) — OTC (yohimbe bark extract — variable potency); Rx.
What this is
Yohimbine HCl and yohimbe bark are distinct — the latter has unpredictable alkaloid content including rauwolscine. Strong adrenergic effects make it dangerous in anxiety-prone individuals. Pairs badly with caffeine or stimulants.
Mechanism
Alkaloid from Pausinystalia johimbe bark; selective α2-adrenergic antagonist; increases peripheral and central noradrenergic tone; historical use for ED before PDE5i era
Dose & route
5-10 mg yohimbine HCl 2-3x/day (fat loss); 10-20 mg PRN (ED)
Citations
- https://pubmed.ncbi.nlm.nih.gov/9609743/
- https://pubmed.ncbi.nlm.nih.gov/16247815/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6323031/
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Common questions
- Does Yohimbine work?
- Read Off Label rates the evidence for Yohimbine as Moderate and the benefit magnitude as moderate, producing an overall grade of C (4.9/10). Yohimbine HCl and yohimbe bark are distinct — the latter has unpredictable alkaloid content including rauwolscine.
- Is Yohimbine safe?
- Yohimbine has a med-high risk profile in published human data. Legal status: OTC (yohimbe bark extract — variable potency); Rx (standardized yohimbine HCl). This is not medical advice — see the disclaimer.
- What is the typical dose for Yohimbine?
- 5-10 mg yohimbine HCl 2-3x/day (fat loss); 10-20 mg PRN (ED)
- How does Yohimbine work?
- Alkaloid from Pausinystalia johimbe bark; selective α2-adrenergic antagonist; increases peripheral and central noradrenergic tone; historical use for ED before PDE5i era
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.