Rankings / Hormones
Hormones
HRT, thyroid replacement, HPG-axis agents, and neurosteroid precursors. Powerful when indicated; outcomes depend heavily on who is taking them and why.
| # | Compound | Ev | Bn | Sf | Grade · Score |
|---|---|---|---|---|---|
| 1 | Elinzanetant (Lynkuet) NK1/NK3 dual receptor antagonist (non-hormonal) | 8.0 | 8.0 | 7.0 | A- 7.6 |
| 2 | Progesterone (micronized / oral / vaginal) Progesterone replacement | 8.0 | 5.0 | 9.0 | B+ 7.3 |
| 3 | Romosozumab (Evenity) Sclerostin antibody (bone anabolic) | 8.0 | 10.0 | 3.5 | B+ 7.2 |
| 4 | Estradiol (HRT — oral/transdermal/vaginal) Estrogen replacement | 8.0 | 8.0 | 5.0 | B+ 7.1 |
| 5 | Fezolinetant (Veozah) NK3 receptor antagonist (non-hormonal) | 8.0 | 8.0 | 5.0 | B+ 7.1 |
| 6 | Resmetirom (Rezdiffra) Liver-selective THR-β agonist | 8.0 | 8.0 | 5.0 | B 6.9 |
| 7 | Gonadorelin (GnRH) Pulsatile GnRH analog | 8.0 | 5.0 | 7.0 | B 6.8 |
| 8 | HCG (human chorionic gonadotropin) LH-analog gonadotropin | 8.0 | 5.0 | 7.0 | B 6.8 |
| 9 | T3 (liothyronine) Active thyroid hormone | 8.0 | 8.0 | 3.5 | B 6.7 |
| 10 | Anastrozole Aromatase inhibitor | 8.0 | 5.0 | 5.0 | B- 6.3 |
| 11 | T4 / NDT (levothyroxine, desiccated thyroid) Thyroid hormone replacement | 8.0 | 5.0 | 5.0 | B- 6.3 |
| 12 | DHEA Adrenal steroid precursor | 6.0 | 3.5 | 7.0 | B- 6.0 |
| 13 | Enclomiphene / Clomiphene SERM (HPG restart) | 6.0 | 5.0 | 5.0 | C+ 5.5 |
| 14 | Pregnenolone Neurosteroid / upstream precursor | 3.0 | 3.5 | 9.0 | C+ 5.3 |