Rankings / Mitochondria & Cellular Energy
BAM15
Mitochondria & Cellular Energy · Mitochondrial uncoupler / exercise mimetic
Tier D
High-risk evidence profile
Bottom line
Read Off Label grades BAM15 as D (2.9/10) based on preclinical evidence, unclear benefit magnitude, and a unknown-high-risk safety profile.
Its high-risk evidence profile reflects a Safety score of 3/10; reported benefits and harms can differ by indication, dose, route, duration, and population.
WADA coverage: 5-N,6-N-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine/BAM15.
Studied, labeled, or reported-use context: No approved human dose — Research chemical; WADA S4 prohibited; not individualized guidance.
What the evidence says
WADA coverage: 5-N,6-N-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine/BAM15. DNP already has its own high-risk row; BAM15 is added separately because it is a named WADA metabolic modulator.
Mechanism
BAM15 is a mitochondrial protonophore explored preclinically for obesity/metabolic disease; it sits in the same conceptual danger zone as uncoupling-for-fat-loss compounds.
Studied, labeled, or reported dose & route
No approved human dose
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about BAM15's effects?
- Read Off Label rates the evidence for BAM15 as Preclinical and the benefit magnitude as unclear, producing an overall grade of D (2.9/10). WADA coverage: 5-N,6-N-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine/BAM15.
- What safety findings are reported for BAM15?
- BAM15 has a unknown-high risk profile in the database. Unknown-High (uncoupler class concerns: hyperthermia, narrow safety margin, off-target mitochondrial toxicity) Legal status: Research chemical; WADA S4 prohibited.
- What does the low Safety score for BAM15 represent?
- The Safety score is 3/10. It records the substantial harms described for one or more use contexts; the Benefit score, indication, dose, route, duration, population, and legal status remain separate parts of the evidence profile.
- What doses or routes are reported for BAM15?
- No approved human dose This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does BAM15 work?
- BAM15 is a mitochondrial protonophore explored preclinically for obesity/metabolic disease; it sits in the same conceptual danger zone as uncoupling-for-fat-loss compounds.
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.